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Dominique Bédard Selected Research

1- (2- (2- (2- (2- methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)- 4- (N'- cyano- N''- (6- (4- chlorophenoxy)hexyl)- N- guanidino)pyridinium

11/2009The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors.
6/2009Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777.

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Dominique Bédard Research Topics

Disease

18Dyskinesias (Dyskinesia)
08/2022 - 01/2018
16Parkinson Disease (Parkinson's Disease)
04/2022 - 01/2018
11Psychotic Disorders (Schizoaffective Disorder)
01/2021 - 01/2018
8Parkinsonian Disorders (Parkinsonism)
08/2022 - 12/2018
2Epilepsy (Aura)
07/2020 - 10/2019
2Neoplasms (Cancer)
11/2009 - 06/2009
1Schizophrenia (Dementia Praecox)
09/2018
1Mental Disorders (Mental Disorder)
09/2018
1Glioblastoma (Glioblastoma Multiforme)
11/2009
1Neuroblastoma
11/2009
1Sarcoma (Soft Tissue Sarcoma)
11/2009
1Multiple Myeloma
06/2009
1Carcinoma (Carcinomatosis)
06/2009
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
06/2009
1Lymphoma (Lymphomas)
06/2009

Drug/Important Bio-Agent (IBA)

18Levodopa (L Dopa)FDA LinkGeneric
08/2022 - 01/2018
131- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
08/2022 - 01/2018
10Serotonin (5 Hydroxytryptamine)IBA
04/2022 - 01/2018
7Oxidopamine (6 Hydroxydopamine)IBA
08/2022 - 01/2019
6Ondansetron (Zofran)FDA LinkGeneric
04/2022 - 10/2019
4Glutamic Acid (Glutamate)FDA Link
04/2020 - 09/2018
3Granisetron (Kytril)FDA LinkGeneric
04/2022 - 01/2021
35-HT2A Serotonin Receptor (5 HT2A Receptor)IBA
02/2019 - 01/2018
25-HT3 Serotonin Receptors (5 HT3 Receptor)IBA
01/2021 - 03/2020
2Monoamine Oxidase (MAO)IBA
11/2020 - 11/2020
2Dopamine (Intropin)FDA LinkGeneric
11/2020 - 03/2020
2Moclobemide (Arima)IBA
11/2020 - 11/2020
2metabotropic glutamate receptor 2IBA
04/2020 - 09/2018
2NAD (NADH)IBA
11/2009 - 06/2009
2N- (6- chlorophenoxyhexyl)- N''- cyano- N''- 4- pyridylguanidine (CHS 828)IBA
11/2009 - 06/2009
21- (2- (2- (2- (2- methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)- 4- (N'- cyano- N''- (6- (4- chlorophenoxy)hexyl)- N- guanidino)pyridiniumIBA
11/2009 - 06/2009
1(4- (3- fluoro- 5- trifluoromethylpyridin- 2- yl)piperazin- 1- yl)(5- methanesulfonyl- 2- (2,2,2- trifluoro- 1- methylethoxy)phenyl)methanoneIBA
08/2022
1Glycine Plasma Membrane Transport ProteinsIBA
08/2022
1(R)- (N- (3- (4'- fluorophenyl)- 3- (4'- phenylphenoxy)propyl))sarcosineIBA
08/2022
1salicylhydroxamic acid (SHAM)IBA
04/2022
1alpha-SynucleinIBA
01/2022
1Serotonin 5-HT3 Receptor AntagonistsIBA
01/2021
1Therapeutic UsesIBA
01/2021
1EnzymesIBA
11/2020
1nefazodone (Serzone)FDA LinkGeneric
12/2018
1Serotonin 5-HT2 Receptor AntagonistsIBA
01/2018
1Messenger RNA (mRNA)IBA
11/2009
1Proteins (Proteins, Gene)FDA Link
11/2009
1ProdrugsIBA
11/2009
1nicotinate phosphoribosyltransferaseIBA
11/2009

Therapy/Procedure

5Therapeutics
01/2021 - 11/2009
1Intravenous Injections
06/2009
1Intravenous Infusions
06/2009